Description

2'-Azetidinomethyl-3,4-Difluorobenzophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique azetidine and difluorobenzophenone structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop next-generation medications, leveraging its specific functional groups to create targeted drug candidates with potential improved efficacy and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders, oncology, or anti-infective applications.
• Protease Inhibitor Research: Used in the development and screening of protease inhibitor candidates, where the azetidine moiety can act as a key pharmacophore.
• Kinase Inhibitor Synthesis: Employed as a building block for creating potential kinase inhibitors, a major class of therapeutics in cancer and inflammatory diseases.
• Chemical Biology & Probe Development: Utilized in academic and industrial research to create chemical probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions for clinical trials.
• Library Synthesis for Drug Discovery: Integral for constructing focused chemical libraries for high-throughput screening (HTS) in early-stage drug discovery programs.

Basic Information

Product Name	2'-Azetidinomethyl-3,4-Difluorobenzophenone
CAS No.	898755-33-4
Molecular Formula	C17H15F2NO
Molecular Weight	287.31 g/mol
Synonyms	3,4-Difluoro-2'-(azetidin-1-ylmethyl)benzophenone; 1-[(3,4-Difluorophenyl)(phenyl)methyl]azetidine; (3,4-Difluorophenyl)(2-(azetidin-1-ylmethyl)phenyl)methanone; Azetidine, 1-[(3,4-difluorophenyl)phenylmethyl]-; 2'-(Azetidin-1-ylmethyl)-3,4-difluorobenzophenone
EINECS	Contact for details

Quality Control

Our 2'-Azetidinomethyl-3,4-Difluorobenzophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.