Description

4'-Chloro-3-(2,6-Dimethylphenyl)-2'-Fluoropropiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its precise molecular architecture, featuring chloro, fluoro, and dimethylphenyl substituents, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical development companies engaged in the creation of novel active pharmaceutical ingredients (APIs) and agrochemicals. CAS No. 898755-16-3.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the synthesis of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Acts as a precursor for the development of specialty polymers and liquid crystals, leveraging its rigid, substituted aromatic core.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, carbonyl chemistry, and fluorination studies to introduce complex molecular fragments.
• Chemical Reference Standard: Supplied as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	4'-Chloro-3-(2,6-Dimethylphenyl)-2'-Fluoropropiophenone
CAS No.	898755-16-3
Molecular Formula	C17H15ClFO
Molecular Weight	292.75 g/mol
Synonyms	2'-Fluoro-4'-chloro-3-(2,6-dimethylphenyl)propiophenone; 1-(4-Chloro-2-fluorophenyl)-3-(2,6-dimethylphenyl)propan-1-one; 898755-16-3; 4'-Chloro-2'-fluoro-3-(2,6-dimethylphenyl)propiophenone; 3-(2,6-Dimethylphenyl)-1-(2-fluoro-4-chlorophenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 4'-Chloro-3-(2,6-Dimethylphenyl)-2'-Fluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.