Description

2'-Chloro-3-(2,6-Dimethylphenyl)-4'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and production of new drugs, where precise chemical building blocks are essential for successful outcomes.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for exploring new chemical reactions and developing novel synthetic methodologies.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation pesticides and herbicides, leveraging its halogenated aromatic core.
• Material Science: Investigated as a monomer or precursor for specialty polymers and advanced organic electronic materials due to its structural properties.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for use in custom synthesis and scale-up projects for pharmaceutical clients.

Basic Information

Product Name	2'-Chloro-3-(2,6-Dimethylphenyl)-4'-Fluoropropiophenone
CAS No.	898755-12-9
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	4'-Fluoro-2'-chloro-3-(2,6-dimethylphenyl)propiophenone; 1-(2-Chloro-4-fluorophenyl)-3-(2,6-dimethylphenyl)propan-1-one; 3-(2,6-Dimethylphenyl)-1-(2-chloro-4-fluorophenyl)propan-1-one; 2'-Chloro-4'-fluoro-3-(2,6-dimethylphenyl)propiophenone; Propiophenone, 2'-chloro-3-(2,6-dimethylphenyl)-4'-fluoro-; CAS 898755-12-9
EINECS	Contact for details

Quality Control

Our 2'-Chloro-3-(2,6-Dimethylphenyl)-4'-Fluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.