Description

2'-Chloro-3-(2,5-Dimethylphenyl)-4'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally-defined building block essential for research and development in modern medicinal chemistry. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on developing new therapeutic agents, particularly in areas requiring fluorinated and chlorinated aromatic systems.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the biological impact of halogenated aromatic moieties.
• API Development: Integral to the process development and scale-up of new Active Pharmaceutical Ingredients (APIs) requiring specific halogen substitution patterns.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized fluorinated and chlorinated organic compounds.
• Academic & Industrial R&D: A valuable reagent for investigating new synthetic methodologies involving ketone and aryl halide functionalities.

Basic Information

Product Name	2'-Chloro-3-(2,5-Dimethylphenyl)-4'-Fluoropropiophenone
CAS No.	898753-90-7
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	1-(2-Chlorophenyl)-3-(2,5-dimethylphenyl)-1-propanone, 4'-Fluoro-2'-chloro-3-(2,5-dimethylphenyl)propiophenone; 3-(2,5-Dimethylphenyl)-1-(2-chloro-4-fluorophenyl)propan-1-one; 898753-90-7; Propiophenone, 2'-chloro-3-(2,5-dimethylphenyl)-4'-fluoro-
EINECS	Contact for details

Quality Control

Our 2'-Chloro-3-(2,5-Dimethylphenyl)-4'-Fluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are available upon request, providing full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.