Description

Ethyl 8-(2,5-Difluorophenyl)-8-Oxooctanoate is a high-purity synthetic intermediate characterized by its difluorophenyl and keto-ester functional groups. This compound is of significant value in advanced organic synthesis, particularly for constructing complex molecules where fluorine substitution is critical for modulating biological activity and physicochemical properties. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for use in medicinal chemistry and active ingredient development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluorophenyl moiety can enhance lipophilicity and environmental stability.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fluorinated Compound Synthesis: An essential precursor for introducing fluorinated aromatic segments into more complex organic molecules, leveraging the unique properties of fluorine.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in regulatory and analytical laboratories.

Basic Information

Product Name	Ethyl 8-(2,5-Difluorophenyl)-8-Oxooctanoate
CAS No.	898753-22-5
Molecular Formula	C₁₆H₂₀F₂O₃
Molecular Weight	298.33 g/mol
Synonyms	Ethyl 8-Oxo-8-(2,5-difluorophenyl)octanoate; 8-(2,5-Difluorophenyl)-8-oxooctanoic Acid Ethyl Ester; Octanoic acid, 8-(2,5-difluorophenyl)-8-oxo-, ethyl ester; 2,5-Difluoro-ω-oxobenzeneoctanoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 8-(2,5-Difluorophenyl)-8-Oxooctanoate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support compliance with cGMP, ICH Q7, and other relevant regulatory guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.