Description

3-(3-Chloro-5-Fluorophenyl)-3',4',5'-Trifluoropropiophenone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a critical building block in the development of complex, bioactive molecules, particularly within the pharmaceutical sector. It is primarily needed by R&D chemists and process development teams in the agrochemical and pharmaceutical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of new drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Material Precursor: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronic Material Research: Employed in the synthesis of novel organic semiconductors and charge-transport materials due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl structures.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specific fluorinated motifs.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-3',4',5'-Trifluoropropiophenone
CAS No.	898751-56-9
Molecular Formula	C15H7ClF4O
Molecular Weight	314.66 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(3,4,5-trifluorophenyl)propan-1-one; 3',4',5'-Trifluoro-3-(3-chloro-5-fluorophenyl)propiophenone; 3-Chloro-5-fluoro-3',4',5'-trifluoropropiophenone; Propiophenone, 3-(3-chloro-5-fluorophenyl)-3',4',5'-trifluoro-; (3-Chloro-5-fluorophenyl)(3,4,5-trifluorophenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-3',4',5'-Trifluoropropiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.