Description

3-(3-Chloro-5-Fluorophenyl)-2',4'-Difluoropropiophenone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a critical building block in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. Industries that require this specialized intermediate include pharmaceutical R&D, agrochemical manufacturing, and advanced material science for creating novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the fluorinated phenyl group enhances bioactivity and environmental stability.
• Liquid Crystal Material R&D: Serves as a fluorinated core component in the development of advanced liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to construct complex polyfluorinated aromatic systems.
• Chemical Research & Development: Utilized in academic and industrial labs for exploring new fluorination methodologies and creating novel chemical entities for screening.
• Material Science: Acts as a monomer or modifier in the synthesis of specialty polymers with enhanced thermal stability and chemical resistance.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-2',4'-Difluoropropiophenone
CAS No.	898751-44-5
Molecular Formula	C15H9ClF3O
Molecular Weight	294.68 g/mol
Synonyms	1-(2,4-Difluorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 2',4'-Difluoro-3-(3-chloro-5-fluorophenyl)propiophenone; 3-(3-Chloro-5-fluorophenyl)-1-(2,4-difluorophenyl)propan-1-one; Propiophenone, 3-(3-chloro-5-fluorophenyl)-2',4'-difluoro-; 898751-44-5; 3-(3-Chloro-5-fluorophenyl)-2,4-difluoropropiophenone
EINECS	Contact for details

Quality Control

Our production of 3-(3-Chloro-5-Fluorophenyl)-2',4'-Difluoropropiophenone adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is subjected to rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.