Description

3-(3-Chloro-5-Fluorophenyl)-3',4'-Dichloropropiophenone is a high-purity, fluorinated and chlorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of complex, biologically active molecules, offering precise structural control for medicinal chemistry and agrochemical research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for constructing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its halogenated aromatic structure.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating novel ligands and catalytic systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Item	Details
Product Name	3-(3-Chloro-5-Fluorophenyl)-3',4'-Dichloropropiophenone
CAS No.	898751-36-5
Molecular Formula	C15H8Cl3FO
Molecular Weight	329.58 g/mol
Synonyms	1-(3,4-Dichlorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 3',4'-Dichloro-3-(3-chloro-5-fluorophenyl)propiophenone; Propiophenone, 3-(3-chloro-5-fluorophenyl)-3',4'-dichloro-; 898751-36-5; 3-(3-Chloro-5-fluorophenyl)-3,4-dichloropropiophenone
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-3',4'-Dichloropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.