Description

3-(3-Chloro-5-Fluorophenyl)-2',4'-Dichloropropiophenone is a specialized fluorinated and chlorinated aromatic ketone intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries requiring high-purity intermediates for research and production, such as pharmaceutical R&D, agrochemical manufacturing, and fine chemical synthesis, are the primary users of this material. Its unique halogenated structure provides specific reactivity for constructing active pharmaceutical ingredients (APIs) and other high-value compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides, leveraging its halogenated phenyl ring for bioactivity.
• Material Science Research: Used in the development of advanced organic materials, including liquid crystals and polymers, where its specific halogen pattern influences molecular properties.
• Organic Synthesis & Catalysis: Employed as a substrate in cross-coupling reactions (e.g., Suzuki, Heck) and other catalytic processes to create complex, multi-substituted aromatic systems.
• Chemical Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling in related chemical processes.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-2',4'-Dichloropropiophenone
CAS No.	898751-28-5
Molecular Formula	C15H8Cl3FO
Molecular Weight	329.58 g/mol
Synonyms	1-(2,4-Dichlorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 2',4'-Dichloro-3-(3-chloro-5-fluorophenyl)propiophenone; 3-(3-Chloro-5-fluorophenyl)-1-(2,4-dichlorophenyl)propan-1-one; Propiophenone, 3-(3-chloro-5-fluorophenyl)-2',4'-dichloro-; 898751-28-5; CAS 898751-28-5
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-2',4'-Dichloropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We are committed to meeting the stringent requirements of research and cGMP-grade production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.