Description

4'-Chloro-3-(3-Chloro-5-Fluorophenyl)-2'-Fluoropropiophenone is a high-purity, multi-halogenated propiophenone derivative serving as a critical advanced pharmaceutical intermediate. Its precise molecular architecture makes it an essential building block for synthesizing complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring structurally sophisticated molecules. This compound is primarily targeted at R&D laboratories and production facilities within the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel, high-value Active Pharmaceutical Ingredients (APIs) with potential CNS or anti-inflammatory activity.
• Agrochemical Research: Used in the development of new-generation herbicides or pesticides, leveraging its halogenated aromatic structure.
• Material Science: Serves as a monomer or cross-linking agent in the research of specialty polymers with unique thermal or chemical resistance properties.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex polycyclic or heterocyclic compounds via reactions like Friedel-Crafts acylation or Suzuki coupling.
• Ligand Synthesis: Potential starting material for creating specialized ligands used in catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	4'-Chloro-3-(3-Chloro-5-Fluorophenyl)-2'-Fluoropropiophenone
CAS No.	898751-20-7
Molecular Formula	C15H8Cl2F2O
Molecular Weight	313.13 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 2-Fluoro-4'-chloro-3-(3-chloro-5-fluorophenyl)propiophenone; 3-(3-Chloro-5-fluorophenyl)-1-(4-chloro-2-fluorophenyl)propan-1-one; 898751-20-7; Propiophenone, 4'-chloro-3-(3-chloro-5-fluorophenyl)-2'-fluoro-
EINECS	Contact for details

Quality Control

Our production of 4'-Chloro-3-(3-Chloro-5-Fluorophenyl)-2'-Fluoropropiophenone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate under a cGMP-compliant mindset suitable for pharmaceutical intermediate applications, ensuring traceability and documentation meet industry expectations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Any single impurity ≤1.0%; Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.