Description

2'-Chloro-3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone is a high-purity fluorinated and chlorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. Its precise molecular architecture makes it a critical building block for the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a core structural unit for developing new-generation herbicides and fungicides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of specialty polymers and liquid crystals due to its halogenated aromatic structure.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitution reactions to introduce complex aryl groups.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	2'-Chloro-3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone
CAS No.	898751-12-7
Molecular Formula	C15H10Cl2F2O
Molecular Weight	315.14 g/mol
Synonyms	1-(2-Chloro-4-fluorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 3-(3-Chloro-5-fluorophenyl)-1-(2-chloro-4-fluorophenyl)propan-1-one; 2'-Chloro-4'-fluoro-3-(3-chloro-5-fluorophenyl)propiophenone; Propiophenone, 2'-chloro-3-(3-chloro-5-fluorophenyl)-4'-fluoro-; 898751-12-7; FCBP Intermediate
EINECS	Contact for details

Quality Control

Our 2'-Chloro-3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.