Description

3-(3-Chloro-5-Fluorophenyl)-4'-Trifluoromethylpropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its distinct halogenated and trifluoromethyl-substituted aromatic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modifications for enhanced efficacy and metabolic stability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Research: Serves as a precursor in the development of new-generation herbicides and pesticides, leveraging its fluorinated structure for improved biological activity and environmental profile.
• Material Science: Used in the research and development of specialty polymers and liquid crystals, where its aromatic and fluorine-containing groups can impart unique thermal and optical properties.
• Organic Synthesis: An essential reagent for cross-coupling reactions, Friedel-Crafts acylations, and other transformations in complex organic molecule construction for research and scale-up.
• Chemical Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-4'-Trifluoromethylpropiophenone
CAS No.	898751-04-7
Molecular Formula	C16H9ClF4O
Molecular Weight	328.69 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]-3-(3-chloro-5-fluorophenyl)propan-1-one; 3-(3-Chloro-5-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]propan-1-one; 4'-Trifluoromethyl-3-(3-chloro-5-fluorophenyl)propiophenone; Propiophenone, 3-(3-chloro-5-fluorophenyl)-4'-(trifluoromethyl)-; 898751-04-7; CAS 898751-04-7
EINECS	Contact for details

Quality Control

Our production of 3-(3-Chloro-5-Fluorophenyl)-4'-Trifluoromethylpropiophenone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Every lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.