Description

3-(3-Chloro-5-Fluorophenyl)-2'-Trifluoromethylpropiophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique structure, featuring chloro, fluoro, and trifluoromethyl substituents, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules with tailored biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals where fluorinated aromatic units are required for specific electronic or surface properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and enzyme inhibitors for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-2'-Trifluoromethylpropiophenone
CAS No.	898750-97-5
Molecular Formula	C16H9ClF4O
Molecular Weight	328.69 g/mol
Synonyms	1-[3-(3-Chloro-5-fluorophenyl)-1-oxopropyl]-2-(trifluoromethyl)benzene; 2'-Trifluoromethyl-3-(3-chloro-5-fluorophenyl)propiophenone; 3-(3-Chloro-5-fluorophenyl)-1-[2-(trifluoromethyl)phenyl]propan-1-one; Propiophenone, 3-(3-chloro-5-fluorophenyl)-2'-(trifluoromethyl)-; 898750-97-5
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-2'-Trifluoromethylpropiophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.