Description

3-(3-Chloro-5-Fluorophenyl)-2'-Fluoropropiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its specific halogenated structure imparts desirable biological activity and metabolic stability. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors engaged in the synthesis of complex, fluorinated molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research pipelines.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine and chlorine substituents enhance efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials for their unique electronic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.
• Academic & Industrial R&D: Utilized in discovery chemistry for structure-activity relationship (SAR) studies and the exploration of new chemical entities.

Basic Information

Item	Detail
Product Name	3-(3-Chloro-5-Fluorophenyl)-2'-Fluoropropiophenone
CAS No.	898750-94-2
Molecular Formula	C15H11ClF2O
Molecular Weight	280.70 g/mol
Synonyms	2'-Fluoro-3-(3-chloro-5-fluorophenyl)propiophenone; 1-[3-(3-Chloro-5-fluorophenyl)-1-oxopropyl]-2-fluorobenzene; 3-(3-Chloro-5-fluorophenyl)-2-fluoropropiophenone; Propiophenone, 3-(3-chloro-5-fluorophenyl)-2'-fluoro-; CAS 898750-94-2
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-2'-Fluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong oxidizing agents, strong bases, and strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.