Description

3'-Chloro-3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone is a high-purity fluorinated and chlorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound is valued for its unique halogenated structure, which makes it a critical building block for constructing complex molecules in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where its halogenated phenyl groups contribute to biological activity and stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its rigid, halogenated aromatic core.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies in cross-coupling reactions and fluorination chemistry.
• Custom Synthesis Building Block: Provided for contract research organizations (CROs) and CDMOs requiring specific, high-purity intermediates for client projects.

Basic Information

Product Name	3'-Chloro-3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone
CAS No.	898750-88-4
Molecular Formula	C15H8Cl2F2O
Molecular Weight	313.13 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 3',4'-Difluoro-3,5'-dichloropropiophenone; 3-Chloro-3-(3-chloro-5-fluorophenyl)-4'-fluoropropiophenone; 898750-88-4; 3-(3-Chloro-5-fluorophenyl)-1-(3-chloro-4-fluorophenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 3'-Chloro-3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material is suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect against moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.