Description

3-(3-Chloro-5-Fluorophenyl)-3',4'-Dimethylpropiophenone is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily required by R&D laboratories, fine chemical manufacturers, and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially in neurological and psychiatric research.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core structural component for constructing complex molecules with targeted biological activity.
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies involving fluorinated and chlorinated aromatic systems.
• Agrochemical Intermediate: Potential application in the development of advanced pesticides and herbicides, leveraging its halogenated aromatic structure.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-3',4'-Dimethylpropiophenone
CAS No.	898750-76-0
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(3,4-dimethylphenyl)propan-1-one; 3',4'-Dimethyl-3-(3-chloro-5-fluorophenyl)propiophenone; Propiophenone, 3-(3-chloro-5-fluorophenyl)-3',4'-dimethyl-; 898750-76-0; 3-(3-Chloro-5-fluorophenyl)-3,4-dimethylpropiophenone
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-3',4'-Dimethylpropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and traceability for demanding pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.