Description

3-(3-Chloro-5-Fluorophenyl)-2',6'-Dimethylpropiophenone is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily needed by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and production of new drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug molecules, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging its halogenated aromatic structure.
• Material Science Research: Serves as a monomer or functional component in the development of specialty polymers and advanced organic materials.
• Academic & Industrial R&D: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-2',6'-Dimethylpropiophenone
CAS No.	898750-73-7
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(2,6-dimethylphenyl)propan-1-one; 3-(3-Chloro-5-fluorophenyl)-1-(2,6-dimethylphenyl)propan-1-one; 2',6'-Dimethyl-3'-(3-chloro-5-fluorobenzoyl)propiophenone; Propiophenone, 3-(3-chloro-5-fluorophenyl)-2',6'-dimethyl-; 3-Chloro-5-fluoro-β,2,6-trimethylpropiophenone
EINECS	Contact for details

Quality Control

Our production of 3-(3-Chloro-5-Fluorophenyl)-2',6'-Dimethylpropiophenone adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. The material is manufactured under controlled conditions and undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we support customer audits and regulatory documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.