Description

3-(3-Chloro-5-Fluorophenyl)-2',5'-Dimethylpropiophenone is a high-purity, advanced pharmaceutical intermediate (API intermediate) characterized by its specific halogenated aromatic structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), where precise molecular architecture is paramount. It is primarily needed by research and development (R&D) laboratories, contract manufacturing organizations (CMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of target drug molecules, especially those requiring halogenated biphenyl or propiophenone motifs.
• Medicinal Chemistry Research: Used extensively in R&D for structure-activity relationship (SAR) studies and the discovery of new chemical entities with potential biological activity.
• API Synthesis: A key raw material in the pilot-scale and commercial-scale production of Active Pharmaceutical Ingredients, where consistent quality is essential for regulatory compliance.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control testing in pharmaceutical manufacturing.
• Agrochemical Intermediate: Potential application in the synthesis of advanced agrochemicals and pesticides, leveraging its halogenated aromatic system.
• Material Science Research: Investigated as a monomer or building block for specialty polymers and advanced organic materials with specific electronic or structural properties.

Basic Information

Item	Details
Product Name	3-(3-Chloro-5-Fluorophenyl)-2',5'-Dimethylpropiophenone
CAS No.	898750-70-4
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(2,5-dimethylphenyl)propan-1-one; 3-(3-Chloro-5-fluorophenyl)-1-(2,5-dimethylphenyl)propan-1-one; 2',5'-Dimethyl-3-(3-chloro-5-fluorophenyl)propiophenone; Propiophenone, 3-(3-chloro-5-fluorophenyl)-2',5'-dimethyl-; 898750-70-4; (3-Chloro-5-fluorophenyl)(2,5-dimethylphenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-2',5'-Dimethylpropiophenone is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect against moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.