Description

3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound is valued for its precise molecular structure, which serves as a key building block for creating complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material science sectors for the development of novel compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, leveraging its fluorinated phenyl groups for enhanced biological activity and stability.
• Material Science Research: Serves as a monomer or building block for synthesizing specialized polymers and liquid crystals with unique optical or electronic properties.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling in API manufacturing.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to construct more complex biaryl structures.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone
CAS No.	898750-61-3
Molecular Formula	C15H11ClF2O
Molecular Weight	280.70 g/mol
Synonyms	1-[4-Fluorophenyl]-3-(3-chloro-5-fluorophenyl)propan-1-one; 4'-Fluoro-3'-(3-chloro-5-fluorophenyl)propiophenone; 3-(3-Chloro-5-fluorophenyl)-1-(4-fluorophenyl)propan-1-one; Propiophenone, 3-(3-chloro-5-fluorophenyl)-4'-fluoro-; 898750-61-3; 3-(3-Chloro-5-fluorophenyl)-4'-fluoropropiophenone
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-4'-Fluoropropiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.