Description

4'-Chloro-3-(3-Chloro-5-Fluorophenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic and crop protection agents. The compound, with CAS number 898750-55-5, is supplied to meet the stringent demands of process chemistry and scale-up production.

Application

This specialized intermediate serves as a key precursor in several high-value synthetic pathways. Its primary applications include:

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex halogenated scaffolds.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, leveraging its fluorinated and chlorinated phenyl groups.
• Chemical Research & Development: Serves as a versatile substrate for method development in organic synthesis, including cross-coupling and functional group transformation reactions.
• Material Science Precursor: Potential use in the synthesis of specialty monomers or ligands for advanced polymeric or coordination complex materials.

Basic Information

Product Name	4'-Chloro-3-(3-Chloro-5-Fluorophenyl)Propiophenone
CAS No.	898750-55-5
Molecular Formula	C15H11Cl2FO
Molecular Weight	297.15 g/mol
Synonyms	1-(4-Chlorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 3-(3-Chloro-5-fluorophenyl)-1-(4-chlorophenyl)-1-propanone; 4'-Chloro-3-(3-chloro-5-fluorophenyl)propiophenone; Propiophenone, 4'-chloro-3-(3-chloro-5-fluorophenyl)-; 898750-55-5
EINECS	Contact for details

Quality Control

Our production of 4'-Chloro-3-(3-Chloro-5-Fluorophenyl)Propiophenone adheres to a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.