Description

3'-Chloro-3-(3-Chloro-5-Fluorophenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its precise molecular architecture enables targeted chemical transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging its halogenated phenyl group for bioactivity.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in scale-up and pilot plant studies for optimizing synthetic routes to final active ingredients.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized fine chemicals for client projects.

Basic Information

Product Name	3'-Chloro-3-(3-Chloro-5-Fluorophenyl)Propiophenone
CAS No.	898750-52-2
Molecular Formula	C15H11Cl2FO
Molecular Weight	297.15 g/mol
Synonyms	1-(3-Chlorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 3-Chloro-3'-(3-chloro-5-fluorophenyl)propiophenone; 3'-Chloro-3-(3-chloro-5-fluorophenyl)-1-phenylpropan-1-one; Propiophenone, 3'-chloro-3-(3-chloro-5-fluorophenyl)-; 898750-52-2; 3-(3-Chloro-5-fluorophenyl)-3'-chloropropiophenone
EINECS	Contact for details

Quality Control

Our 3'-Chloro-3-(3-Chloro-5-Fluorophenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.