Description

4'-Bromo-3-(3-Chloro-5-Fluorophenyl)Propiophenone is a high-value halogenated aromatic ketone building block, specifically designed for advanced organic synthesis. Its precise molecular architecture, featuring bromo, chloro, and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a versatile building block for developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of its halogenated phenylpropiophenone core.
• Material Science Research: Used in the development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or monomers for specialty polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	4'-Bromo-3-(3-Chloro-5-Fluorophenyl)Propiophenone
CAS No.	898750-49-7
Molecular Formula	C15H11BrClFO
Molecular Weight	356.60 g/mol
Synonyms	1-(4-Bromophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one; 3-(3-Chloro-5-fluorophenyl)-1-(4-bromophenyl)propan-1-one; 4'-Bromo-3-(3-chloro-5-fluorophenyl)propiophenone; Propiophenone, 4'-bromo-3-(3-chloro-5-fluorophenyl)-; 898750-49-7; (3-Chloro-5-fluorophenyl)(4-bromophenyl)propanone
EINECS	Contact for details

Quality Control

Our 4'-Bromo-3-(3-Chloro-5-Fluorophenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and cGMP (Current Good Manufacturing Practice) starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.