Description

3-(3-Chloro-5-Fluorophenyl)-2'-Thiomethylpropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated aromatic and thiomethyl ketone structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) targeting specific therapeutic pathways. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its halogenated phenyl group for bioactivity.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, including Suzuki-Miyaura cross-coupling and nucleophilic substitution reactions.
• Material Science: Potential intermediate in the research and development of specialty polymers and advanced organic electronic materials.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under cGMP guidelines.

Basic Information

Product Name	3-(3-Chloro-5-Fluorophenyl)-2'-Thiomethylpropiophenone
CAS No.	898750-40-8
Molecular Formula	C16H14ClFOS
Molecular Weight	308.80 g/mol
Synonyms	3-(3-Chloro-5-fluorophenyl)-2'-(methylthio)propiophenone; 1-[3-(3-Chloro-5-fluorophenyl)propanoyl]-2-(methylthio)benzene; 2'-(Methylthio)-3-(3-chloro-5-fluorophenyl)propiophenone; Propiophenone, 3-(3-chloro-5-fluorophenyl)-2'-(methylthio)-; 898750-40-8; CAS 898750-40-8
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorophenyl)-2'-Thiomethylpropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.