Description

3'-Carboethoxy-3-(3-Chloro-5-Fluorophenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is essential for R&D laboratories and manufacturing facilities in the global pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Organic Synthesis Building Block: Used in research and development for constructing complex molecular architectures via reactions at the ketone and ester functional groups.
• Agrochemical Research: Potential intermediate for developing new active ingredients in crop protection products, leveraging the chloro-fluorophenyl moiety.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and advanced organic materials with specific optical or electronic properties.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Item	Detail
Product Name	3'-Carboethoxy-3-(3-Chloro-5-Fluorophenyl)Propiophenone
CAS No.	898750-34-0
Molecular Formula	C18H16ClFO3
Molecular Weight	334.77 g/mol
Synonyms	Ethyl 3-(3-chloro-5-fluorophenyl)-3-oxopropanoate; 3-Oxo-3-(3-chloro-5-fluorophenyl)propanoic acid ethyl ester; 3-(3-Chloro-5-fluorophenyl)-3-oxopropionic acid ethyl ester; Ethyl 3-(3-chloro-5-fluorobenzoyl)acetate; 898750-34-0; 3'-Carbethoxy-3-(3-chloro-5-fluorophenyl)propiophenone
EINECS	Contact for details

Quality Control

Our 3'-Carboethoxy-3-(3-Chloro-5-Fluorophenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.