Description

4-Bromo-2-Fluoro-3'-(3-Pyrrolinomethyl) Benzophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated benzophenone structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific bromo-fluoro substitution patterns into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and scale-up synthesis of potential drug candidates, particularly in oncology and CNS therapeutic areas.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its reactive halogen sites and functionalized pyrrolidine moiety.
• Agrochemical Research: Serves as a precursor in the development of new herbicides or fungicides where the benzophenone core is functional.
• Chemical Biology Probe Development: Employed in the synthesis of molecular probes and tags for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.
• Academic & Institutional Research: Used in university and institutional labs for pioneering research in organic synthesis and new reaction methodologies.

Basic Information

Item	Details
Product Name	4-Bromo-2-Fluoro-3'-(3-Pyrrolinomethyl) Benzophenone
CAS No.	898749-35-4
Molecular Formula	C18H17BrFNO
Molecular Weight	362.24 g/mol
Synonyms	4-Bromo-2-fluoro-3'-(pyrrolidin-3-ylmethyl)benzophenone; 3'-[(3-Pyrrolidinyl)methyl]-4-bromo-2-fluorobenzophenone; Benzophenone, 4-bromo-2-fluoro-3'-(3-pyrrolidinylmethyl)-; 898749-35-4; 4-Bromo-2-fluoro-3'-(3-pyrrolidinylmethyl)benzophenone; 3'-(3-Pyrrolidinylmethyl)-4-bromo-2-fluorobenzophenone
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Fluoro-3'-(3-Pyrrolinomethyl) Benzophenone is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with specifications for residual solvents and related substances. Certificates of Analysis (COA) documenting batch-specific results are available upon request. We support development projects with the capability to produce custom grades, including research and cGMP-quality material for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.