Description

Pentafluorophenyl 4-(1,3-Oxazol-5-Yl)Benzoate is a high-purity, specialized organic building block designed for advanced synthetic chemistry. This compound is valued for its unique molecular architecture, which incorporates both a reactive pentafluorophenyl ester group and an oxazole heterocycle, making it a versatile intermediate for constructing complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as medicinal chemistry, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for introducing the oxazole pharmacophore and facilitating subsequent coupling reactions via its activated ester.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the oxazole ring can contribute to biological activity and the ester allows for further structural diversification.
• Materials Science Precursor: Employed in the synthesis of advanced organic materials, such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs), due to its rigid, conjugated structure.
• Bioconjugation & Probe Development: The pentafluorophenyl ester is highly reactive towards amines, making this compound useful for labeling biomolecules, creating fluorescent probes, or modifying peptides and proteins in biochemical research.
• Cross-Coupling & Catalysis: Acts as a substrate or ligand precursor in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and for exploring new chemical spaces in academic and industrial R&D laboratories.

Basic Information

Product Name	Pentafluorophenyl 4-(1,3-Oxazol-5-Yl)Benzoate
CAS No.	898288-91-0
Molecular Formula	C₁₆H₆F₅NO₃
Molecular Weight	355.22 g/mol
Synonyms	4-(1,3-Oxazol-5-yl)benzoic acid pentafluorophenyl ester; Pentafluorophenyl 4-(oxazol-5-yl)benzoate; 5-[4-[(Pentafluorophenoxy)carbonyl]phenyl]-1,3-oxazole; PFP 4-Oxazolylbenzoate
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 4-(1,3-Oxazol-5-Yl)Benzoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity (IR, NMR), purity (HPLC), and impurity profile. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.