Description

3-Boc-1-Methyl-6-Oxa-3-Azabicyclo[3.1.0]Hexane is a high-value, protected bicyclic amine derivative used as a key synthetic intermediate in advanced organic chemistry. This compound is critical for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process R&D, and the synthesis of nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies to explore new chemical space and optimize drug-like properties.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the development of scalable, cost-effective synthetic routes for potential APIs.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides that require complex, nitrogen-rich bicyclic structures.
• Academic & Contract Research: Utilized in universities and CROs for methodological studies in organic synthesis, including ring-opening and functionalization reactions.
• Peptidomimetics & PROTACs: Acts as a constrained, rigid scaffold in the design of peptide mimics and bifunctional molecules like PROTACs (Proteolysis Targeting Chimeras).

Basic Information

Item	Detail
Product Name	3-Boc-1-Methyl-6-Oxa-3-Azabicyclo[3.1.0]Hexane
CAS No.	897445-50-0
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	1-Methyl-3-[(tert-butoxy)carbonyl]-6-oxa-3-azabicyclo[3.1.0]hexane; tert-Butyl 1-methyl-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate; 3-Boc-1-methyl-6-oxa-3-azabicyclo[3.1.0]hexane; 1-Methyl-3-Boc-6-oxa-3-azabicyclo[3.1.0]hexane; Bicyclo[3.1.0]hexane, 3-[(1,1-dimethylethoxy)carbonyl]-1-methyl-6-oxa-3-aza-; 3-(tert-Butoxycarbonyl)-1-methyl-6-oxa-3-azabicyclo[3.1.0]hexane
EINECS	Contact for details

Quality Control

Our 3-Boc-1-Methyl-6-Oxa-3-Azabicyclo[3.1.0]Hexane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.