Description

(S)-1-(4-Bromophenyl)-2'-((S)-1-(4-Bromophenyl)-3,3-Dimethyl-4-Oxoazetidin-2-Yloxy)-3,3,5'-Trimethylspiro[Azetidine-2.3'-Indoline]-4-One is a high-purity, complex chiral spiro compound featuring a unique azetidine-indoline scaffold. This molecule is of significant value as a sophisticated pharmaceutical intermediate or advanced building block in organic synthesis, enabling the construction of novel, biologically active structures. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new chemical entities, particularly for targeted therapies and asymmetric synthesis programs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and development of novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Asymmetric Synthesis: Utilized in the stereoselective construction of complex molecules due to its defined (S)-configuration at multiple chiral centers.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in high-throughput screening.
• Chemical Biology Probes: Used to develop molecular probes for studying enzyme mechanisms or protein-ligand interactions, leveraging its specific 3D architecture.
• Process Chemistry Development: Acts as a critical intermediate in scaling up synthetic routes for potential drug candidates during the process research and development (PR&D) phase.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for fine chemical suppliers offering bespoke synthesis services to the pharmaceutical industry.

Basic Information

Product Name	(S)-1-(4-Bromophenyl)-2'-((S)-1-(4-Bromophenyl)-3,3-Dimethyl-4-Oxoazetidin-2-Yloxy)-3,3,5'-Trimethylspiro[Azetidine-2.3'-Indoline]-4-One
CAS No.	896746-35-3
Molecular Formula	C34H33Br2N3O4
Molecular Weight	707.46 g/mol
Synonyms	(S)-1-(4-Bromophenyl)-2'-((S)-1-(4-Bromophenyl)-3,3-dimethyl-4-oxoazetidin-2-yloxy)-3,3,5'-trimethylspiro[azetidine-2,3'-indolin]-4-one; Spiro[azetidine-2,3'-indoline] derivative; Chiral Azetidine-Indoline Spiro Compound; 896746-35-3; (S,S)-Bromophenyl Dimethyl Oxoazetidinyloxy Trimethylspiro Compound; Advanced Pharmaceutical Building Block; Complex Chiral Spiro Intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.