Description

4-Hydroxy-4'-(Trifluoromethyl)[1,1'-Biphenyl]-3- Carbaldehyde is a specialized biphenyl derivative featuring both a phenolic hydroxyl group and a trifluoromethyl substituent, making it a valuable multifunctional building block in advanced organic synthesis. Its unique structure offers significant potential for modulating the electronic and steric properties of target molecules, which is critical for developing high-performance materials and active pharmaceutical ingredients. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging its biphenyl core and fluorine content to enhance pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a core building block for advanced electronic materials, where its rigid, conjugated structure and polar groups are essential for creating stable liquid crystal phases and efficient organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into polymer backbones or as a cross-linking agent to impart specific characteristics like thermal stability, chemical resistance, or unique optical properties to high-performance plastics and coatings.
• Ligand & Catalyst Development: Utilized in organometallic chemistry to create novel chelating ligands for catalysis, particularly in asymmetric synthesis and cross-coupling reactions critical for fine chemical manufacturing.
• Academic & Industrial R&D: Employed as a standard or investigational compound in research laboratories for method development, structure-activity relationship (SAR) studies, and exploring new chemical spaces.

Basic Information

Product Name	4-Hydroxy-4'-(Trifluoromethyl)[1,1'-Biphenyl]-3- Carbaldehyde
CAS No.	893737-67-2
Molecular Formula	C14H9F3O2
Molecular Weight	266.22 g/mol
Synonyms	[1,1'-Biphenyl]-3-carboxaldehyde, 4-hydroxy-4'-(trifluoromethyl)-; 4'-Trifluoromethyl-4-hydroxybiphenyl-3-carbaldehyde; 3-Formyl-4'-trifluoromethyl-4-hydroxybiphenyl; 4-Hydroxy-4'-trifluoromethylbiphenyl-3-carboxaldehyde; 4-Hydroxy-4'-(trifluoromethyl)biphenyl-3-carbaldehyde; 893737-67-2; 4-Hydroxy-4'-(trifluoromethyl)-1,1'-biphenyl-3-carbaldehyde
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxy-4'-(Trifluoromethyl)[1,1'-Biphenyl]-3- Carbaldehyde adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR and IR for structural confirmation, and GC-MS for residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.