Description

5,5,5-Trifluoro-2,4-Dioxo-Pentanoic Acid Ethyl Ester is a high-value fluorinated β-keto ester building block, essential for introducing the trifluoromethyl group into complex molecular architectures. Its unique structure makes it a critical intermediate for synthesizing advanced pharmaceuticals and agrochemicals, where the CF3 moiety is prized for enhancing metabolic stability and lipophilicity. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethyl groups, particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Fluorinated Material Precursor: Serves as a starting material for creating specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated segments.
• Chemical Research & Development: A versatile reagent in medicinal chemistry and process chemistry for constructing complex, fluorinated heterocycles and scaffolds via condensation and cyclization reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	5,5,5-Trifluoro-2,4-Dioxo-Pentanoic Acid Ethyl Ester
CAS No.	893643-18-0
Molecular Formula	C7H7F3O4
Molecular Weight	212.12 g/mol
Synonyms	Ethyl 5,5,5-Trifluoro-2,4-dioxopentanoate; Ethyl 5,5,5-Trifluoro-3-oxopentanedioate; 5,5,5-Trifluoro-3-oxoglutaric Acid Ethyl Ester; 3-Oxo-5,5,5-trifluoroglutaric Acid Ethyl Ester; TFOG Ethyl Ester; Trifluoromethyl Diketone Ester; 2,4-Dioxo-5,5,5-trifluoropentanoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Every batch of 5,5,5-Trifluoro-2,4-Dioxo-Pentanoic Acid Ethyl Ester is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or stored in dark conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.