Description

tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate CAS NO 893566-72-8 is a high-purity, protected boronic ester derivative of tetrahydroisoquinoline, serving as a critical advanced pharmaceutical intermediate (API) and building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in pharmaceutical R&D and fine chemical synthesis, particularly for developing novel drug candidates targeting central nervous system and oncological pathways.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel therapeutic agents, especially in central nervous system (CNS) and oncology drug discovery pipelines.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of biaryl and other carbon-carbon bonds in complex molecule assembly.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for lead optimization.
• Fine Chemical Synthesis: Intermediate for creating specialty chemicals, agrochemicals, and advanced materials requiring the tetrahydroisoquinoline scaffold.
• Process Chemistry Development: Serves as a standardized reagent for scaling up synthetic routes from laboratory to pilot and commercial production.
• Academic Research: A valuable tool for methodological development in organic synthesis and catalysis studies at universities and research institutes.

Basic Information

Item	Details
Product Name	tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	893566-72-8
Molecular Formula	C20H30BNO4
Molecular Weight	359.27 g/mol
Synonyms	tert-Butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; 1-Boc-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline; N-Boc-6-Pinacolboron-Tetrahydroisoquinoline; 6-Pinacolboryl-N-Boc-1,2,3,4-tetrahydroisoquinoline; 893566-72-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding applications in pharmaceutical development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all relevant specifications. Our quality system is designed to support cGMP compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.