Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One is a high-value pharmaceutical intermediate and versatile synthetic building block featuring a pinacol boronate ester group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those containing indolinone scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable organoboron reagent for palladium-catalyzed coupling with aryl/vinyl halides to form biaryl structures.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new therapeutic targets.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science: A building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One
CAS No.	893441-85-5
Molecular Formula	C14H18BNO3
Molecular Weight	259.11 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-indol-2-one; 6-(Pinacolatoboryl)indolin-2-one; 2-Oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline; 6-(Pinacolboron)indolin-2-one; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-indolinone; 6-(Pinacolato)borylindolin-2-one; 6-Boronopinacol indolin-2-one
EINECS	Contact for details

Quality Control

Our 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production use. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant standards for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.