Description

Benzyl 2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ylcarbamate is a high-value, organoboron-protected pyridine derivative, serving as a critical synthetic intermediate in modern pharmaceutical and agrochemical research. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex pyridine and biaryl motifs.
• Medicinal Chemistry Research: Used in high-throughput screening and lead optimization for creating novel drug candidates targeting various diseases.
• Agrochemical Synthesis: Intermediate in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science: Precursor for organic electronic materials, such as ligands for OLEDs or molecular components for organic semiconductors.
• Cross-Coupling Reactions: Specifically designed as a boronic ester partner in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds.
• Chemical Biology Probes: Used to create tagged molecules or probes for studying biological processes and target engagement.

Basic Information

Item	Details
Product Name	Benzyl 2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ylcarbamate
CAS No.	893440-45-4
Molecular Formula	C20H25BN2O5
Molecular Weight	384.24 g/mol
Synonyms	Benzyl N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)carbamate; 3-(((Benzyloxy)carbonyl)amino)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine, N-Cbz derivative; Pinacol ester of (3-(((Benzyloxy)carbonyl)amino)-2-methoxypyridin-5-yl)boronic acid; 893440-45-4; Benzyl carbamate pyridine boronic ester
EINECS	Contact for details

Quality Control

Our Benzyl 2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ylcarbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%; Any single impurity ≤1.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.