Description

(Z)-3-(3-Phenylprop-2-Ynylidene)-2-(Trifluoromethyl)Tetrahydro-2H-Pyran-2-Ol is a high-value, fluorinated organic building block characterized by its unique combination of a trifluoromethyl group and a conjugated enyne system. This compound is critical for advanced research and development, offering a versatile scaffold for modulating the physicochemical properties of target molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel drug candidates, particularly where the introduction of a trifluoromethyl group is desired to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom's ability to improve biological activity and environmental persistence profiles.
• Material Science Precursor: Acts as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its rigid, conjugated structure and fluorine content.
• Chemical Biology Probe Development: Employed in the design of molecular probes and tags for studying biological systems, where its distinct chemical handle allows for selective labeling or modulation.
• Catalysis & Ligand Synthesis: Utilized as a precursor for creating novel chiral ligands or organocatalysts, exploiting the stereogenic center and functional groups for asymmetric synthesis applications.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic synthesis, including cycloaddition reactions and cross-coupling methodologies.

Basic Information

Item	Details
Product Name	(Z)-3-(3-Phenylprop-2-Ynylidene)-2-(Trifluoromethyl)Tetrahydro-2H-Pyran-2-Ol
CAS No.	893428-03-0
Molecular Formula	C15H13F3O2
Molecular Weight	282.26 g/mol
Synonyms	(Z)-3-(3-Phenyl-2-propynylidene)-2-(trifluoromethyl)tetrahydro-2H-pyran-2-ol; 2-(Trifluoromethyl)-3-[(1Z)-3-phenyl-2-propyn-1-ylidene]tetrahydro-2H-pyran-2-ol; 893428-03-0; (Z)-enynyl trifluoromethyl pyranol derivative; Fluorinated enyne pyranol building block
EINECS	Contact for details

Quality Control

Our production of (Z)-3-(3-Phenylprop-2-Ynylidene)-2-(Trifluoromethyl)Tetrahydro-2H-Pyran-2-Ol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to light (store away from light) and may be incompatible with strong bases and fluorides. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.