Description

2-(3,4-Dihydro-2H-Pyran-5-Yl)-1,1,1-Trifluoro-4-Phenylbut-3-Yn-2-Ol CAS NO 893428-01-8 is a high-value, multi-functional organic intermediate featuring a unique trifluoromethylated propargylic alcohol core fused with a dihydropyran ring. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the efficient construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its rigid, fluorinated structure to modify material properties.
• Fluorine Chemistry: An essential reagent for introducing the trifluoromethyl group and alkyne functionality into complex molecules in a single step.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in asymmetric synthesis and catalysis.

Basic Information

Product Name	2-(3,4-Dihydro-2H-Pyran-5-Yl)-1,1,1-Trifluoro-4-Phenylbut-3-Yn-2-Ol
CAS No.	893428-01-8
Molecular Formula	C15H13F3O2
Molecular Weight	282.26 g/mol
Synonyms	5-(1,1,1-Trifluoro-4-phenyl-3-butyn-2-ol)-3,4-dihydro-2H-pyran; 1,1,1-Trifluoro-4-phenyl-2-(3,4-dihydro-2H-pyran-5-yl)-3-butyn-2-ol; 2-(3,4-Dihydro-2H-pyran-5-yl)-1,1,1-trifluoro-4-phenyl-3-butyn-2-ol; 893428-01-8; Trifluoromethylated propargylic alcohol dihydropyran derivative; 5-(2-Hydroxy-1,1,1-trifluoro-4-phenylbut-3-yn-2-yl)-3,4-dihydro-2H-pyran
EINECS	Contact for details

Quality Control

Our 2-(3,4-Dihydro-2H-Pyran-5-Yl)-1,1,1-Trifluoro-4-Phenylbut-3-Yn-2-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.