Description

2-(4,5-Dihydrofuran-3-Yl)-1,1,1-Trifluoro-4-Phenylbut-3-Yn-2-Ol is a specialized fluorinated organic building block featuring a unique dihydrofuran and phenylacetylene scaffold. This compound matters for its role as a key synthetic intermediate in the development of advanced pharmaceuticals and agrochemicals, where its trifluoromethyl group and complex structure enable precise modulation of biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers and liquid crystals with tailored optical or electronic properties.
• Chemical Synthesis: Acts as a versatile building block for constructing complex natural product analogs and other high-value fine chemicals via Sonogashira coupling and other metal-catalyzed reactions.
• Fluorine Chemistry Research: An important compound for academic and industrial research exploring the effects of fluorination on molecular conformation and reactivity.

Basic Information

Product Name	2-(4,5-Dihydrofuran-3-Yl)-1,1,1-Trifluoro-4-Phenylbut-3-Yn-2-Ol
CAS No.	893428-00-7
Molecular Formula	C15H11F3O2
Molecular Weight	280.24 g/mol
Synonyms	1,1,1-Trifluoro-4-phenyl-2-(3-furanyl)-3-butyn-2-ol; 2-(4,5-Dihydro-3-furanyl)-1,1,1-trifluoro-4-phenyl-3-butyn-2-ol; 3-Butyn-2-ol, 1,1,1-trifluoro-4-phenyl-2-(4,5-dihydro-3-furanyl)-; 1,1,1-Trifluoro-4-phenyl-2-(4,5-dihydrofuran-3-yl)but-3-yn-2-ol; 893428-00-7; FC-893428-00-7
EINECS	Contact for details

Quality Control

Our production of 2-(4,5-Dihydrofuran-3-Yl)-1,1,1-Trifluoro-4-Phenylbut-3-Yn-2-Ol adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.