Description

2-Carboxy-4-Chlorophenylboronic Acid Pinacol Ester is a high-value, multifunctional boronic ester building block crucial for modern synthetic chemistry. This compound is specifically engineered to provide enhanced stability and reactivity for the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is an essential intermediate for medicinal chemists and process development scientists engaged in Suzuki-Miyaura cross-coupling reactions and other advanced transformations.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific chlorophenyl and carboxylic acid functionalities.
• Material Science Research: Serves as a monomer or precursor for advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group protects the boronic acid, offering improved handling and stability for palladium-catalyzed carbon-carbon bond formation.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes, sensors, and inhibitors that target specific enzymes or biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Carboxy-4-Chlorophenylboronic Acid Pinacol Ester
CAS No.	891843-31-5
Molecular Formula	C13H16BClO4
Molecular Weight	282.53 g/mol
Synonyms	(4-Chloro-2-(methoxycarbonyl)phenyl)boronic acid pinacol ester; 2-(Methoxycarbonyl)-4-chlorophenylboronic acid pinacol ester; Methyl 4-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 4-Chloro-2-(methoxycarbonyl)benzeneboronic acid pinacol ester; Pinacol (4-chloro-2-(methoxycarbonyl)phenyl)boronate; CAS 891843-31-5
EINECS	Contact for details

Quality Control

Our 2-Carboxy-4-Chlorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.