Description

7,8-Difluorochroman-4-One is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral precursor for developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need it for constructing next-generation drug candidates, agrochemicals, and specialty materials where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A crucial synthon for the synthesis of fluorinated drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Research: Serves as a building block for developing new-generation herbicides, fungicides, and pesticides with enhanced efficacy and environmental profile.
• Material Science: Used in the research and development of advanced organic electronic materials and liquid crystals, where fluorination improves performance.
• Chemical Biology & Probe Development: Employed as a scaffold for creating fluorescent probes and molecular tools to study biological systems.
• Asymmetric Synthesis: Acts as a chiral starting material or resolving agent for the production of enantiomerically pure compounds.
• Custom Synthesis & Contract Manufacturing: A key requested molecule for bespoke synthesis projects in CDMO (Contract Development and Manufacturing Organization) settings.

Basic Information

Product Name	7,8-Difluorochroman-4-One
CAS No.	890840-90-1
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	7,8-Difluoro-4-chromanone; 4H-1-Benzopyran-4-one, 7,8-difluoro-2,3-dihydro-; 7,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-one; 7,8-Difluoro-2,3-dihydro-4H-chromen-4-one; 7,8-Difluoro-4-chromone; 7,8-Difluorodihydrochromen-4-one; 7,8-Difluorochromanone
EINECS	Contact for details

Quality Control

Our 7,8-Difluorochroman-4-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.