Description

Methyl 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoate is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile intermediate for the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or substituted phenyl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides through palladium-catalyzed cross-coupling methodologies.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	Methyl 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoate
CAS No.	890839-11-9
Molecular Formula	C₁₆H₂₃BO₄
Molecular Weight	290.16 g/mol
Synonyms	2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid methyl ester; Methyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoate; 2-(4-Pinacolatoboranephenyl)propionic Acid Methyl Ester; 4-(Methoxycarbonylethyl)phenylboronic Acid Pinacol Ester; (4-(1-Methoxy-1-oxopropan-2-yl)phenyl)boronic Acid Pinacol Ester; Methyl α-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenepropanoate
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to prevent hydrolysis of the boronic ester functionality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.