Description

n-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropyl)Methanesulfonamide is a high-value, advanced pharmaceutical intermediate featuring a unique cyclopropyl and pinacol boronate ester structure. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl scaffolds. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active pharmaceutical ingredients (APIs) and other complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting CNS disorders, oncology, and inflammatory diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds between the boronate ester and aryl/vinyl halides, enabling the construction of complex, drug-like biaryl structures.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug potency and selectivity.
• Process Chemistry Development: Serves as a critical starting material for scaling up the synthesis of target molecules from laboratory to pilot plant and commercial production.
• Ligand and Catalyst Synthesis: Used in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other advanced transformations.
• Agrochemical and Material Science R&D: Applied in the discovery of new active ingredients for crop protection and in the synthesis of advanced organic electronic materials.

Basic Information

Product Name	n-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropyl)Methanesulfonamide
CAS No.	890172-55-1
Molecular Formula	C16H24BNO4S
Molecular Weight	337.24 g/mol
Synonyms	N-[1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl]methanesulfonamide; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanamine, N-methanesulfonyl derivative; Methanesulfonamide, N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl]-; BCPM; Cyclopropyl Boronate Ester Sulfonamide; Pinacol Boronate Ester Intermediate; Suzuki Coupling Boronic Ester
EINECS	Contact for details

Quality Control

Our n-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropyl)Methanesulfonamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced under GMP-like conditions where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.