Description

3-(2-Carboxy-Phenyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-value pyrrolidine-based building block featuring both a carboxylic acid and a tert-butyl ester protecting group. This compound is critical for synthetic chemists as it provides a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily used by R&D teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates, particularly those targeting neurological and metabolic disorders.
• Protease Inhibitor Synthesis: Used in the research and development of protease inhibitors due to its pyrrolidine scaffold.
• Agrochemical Active Ingredient Development: Serves as a precursor in creating novel herbicides and fungicides.
• Peptidomimetics Research: Employed in the design and synthesis of peptidomimetic compounds for medicinal chemistry applications.
• Ligand and Catalyst Development: Utilized as a chiral precursor or ligand in asymmetric synthesis and catalysis.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP conditions.

Basic Information

Product Name	3-(2-Carboxy-Phenyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	889953-29-1
Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34 g/mol
Synonyms	1-Boc-3-(2-carboxyphenyl)pyrrolidine; tert-Butyl 3-(2-carboxyphenyl)pyrrolidine-1-carboxylate; 3-(2-Carboxyphenyl)-1-(tert-butoxycarbonyl)pyrrolidine; 1-N-Boc-3-(2-carboxyphenyl)pyrrolidine; 3-(2-Carboxy-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester; Pyrrolidine-1-carboxylic acid, 3-(2-carboxyphenyl)-, 1,1-dimethylethyl ester; BOC-3-(2-COOH-Ph)-pyrrolidine
EINECS	Contact for details

Quality Control

Our 3-(2-Carboxy-Phenyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications from research to development and commercial-scale cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.