Description

4-(Tetrahydro-2H-Pyran-2-Yloxy)Phenylboronic Acid Pinacol Ester is a protected boronic acid derivative, a crucial intermediate in modern synthetic organic chemistry. Its primary value lies in its enhanced stability compared to the free boronic acid, making it an ideal reagent for Suzuki-Miyaura cross-coupling reactions under demanding conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require a reliable, shelf-stable building block for constructing complex biaryl and heterobiaryl structures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex aryl-aryl linkages.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific biaryl motifs.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as polymers for OLEDs and OFETs.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital reagent for fine chemical and custom synthesis houses serving global R&D projects.

Basic Information

Product Name	4-(Tetrahydro-2H-Pyran-2-Yloxy)Phenylboronic Acid Pinacol Ester
CAS No.	889865-38-7
Molecular Formula	C₁₇H₂₅BO₄
Molecular Weight	304.19 g/mol
Synonyms	4-(Tetrahydro-2H-pyran-2-yloxy)benzeneboronic acid pinacol ester; 2-[4-(Oxan-2-yloxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(THP-O)C₆H₄Bpin; 4-(Tetrahydropyran-2-yloxy)phenylboronic acid pinacol ester; PINACOL 4-(TETRAHYDRO-2H-PYRAN-2-YLOXY)PHENYLBORONATE
EINECS	Contact for details

Quality Control

Our 4-(Tetrahydro-2H-Pyran-2-Yloxy)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure high purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.