Description

5-(2,5-Difluorophenyl)Nicotinaldehyde is a high-purity fluorinated nicotinaldehyde derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique difluorophenyl-pyridine hybrid structure, which is essential for modulating the pharmacokinetic and binding properties of novel drug candidates. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Chemical Biology: Serves as a versatile precursor for creating molecular probes and labeled compounds used in drug discovery and diagnostic assays.
• Material Science: Potential monomer or precursor for specialty polymers and liquid crystals, where the rigid, fluorinated aromatic core can impart specific electronic or thermal properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploring new chemical spaces in heterocyclic and fluoroorganic chemistry.

Basic Information

Product Name	5-(2,5-Difluorophenyl)Nicotinaldehyde
CAS No.	887973-84-4
Molecular Formula	C12H7F2NO
Molecular Weight	219.19 g/mol
Synonyms	5-(2,5-Difluorophenyl)-3-pyridinecarboxaldehyde; 3-Pyridinecarboxaldehyde, 5-(2,5-difluorophenyl)-; 5-(2,5-Difluorophenyl)pyridine-3-carbaldehyde; 5-(2,5-Difluorophenyl)nicotinaldehyde; Nicotinaldehyde, 5-(2,5-difluorophenyl)-; 5-(2,5-Difluorophenyl)-3-formylpyridine
EINECS	Contact for details

Quality Control

Our 5-(2,5-Difluorophenyl)Nicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.