Description

1-Boc-3-[(2-Fluorobenzyl-Amino)-Methyl]-Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolidine scaffold with a fluorinated benzylamine side chain. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and target affinity. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic laboratories engaged in the discovery of new therapeutic agents, particularly in the areas of central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting G-protein coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of various protease enzymes.
• Peptidomimetic Synthesis: Employed to create non-peptide analogs that mimic the structure and function of bioactive peptides.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Library Synthesis for High-Throughput Screening: A valuable reactant for generating diverse compound libraries for drug discovery campaigns.

Basic Information

Product Name	1-Boc-3-[(2-Fluorobenzyl-Amino)-Methyl]-Pyrrolidine
CAS No.	887590-96-7
Molecular Formula	C18H27FN2O2
Molecular Weight	322.42 g/mol
Synonyms	tert-Butyl 3-({[(2-fluorophenyl)methyl]amino}methyl)pyrrolidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(2-fluorobenzylamino)methyl]pyrrolidine; N-[(2-Fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-methanamine; 1-Boc-3-(2-fluorobenzylaminomethyl)pyrrolidine; Boc-3-[(2-Fluorobenzylamino)Methyl]Pyrrolidine; 3-[(2-Fluorobenzylamino)methyl]-1-Boc-pyrrolidine; Pyrrolidine, 3-[[[(2-fluorophenyl)methyl]amino]methyl]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1-Boc-3-[(2-Fluorobenzyl-Amino)-Methyl]-Pyrrolidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.