Description

5-Bromo-2,3-Difluorobenzyl Amine is a high-purity, multi-functional aromatic amine building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of bromine and fluorine substituents on the benzyl amine core, which allows for precise structural modifications and the introduction of key pharmacophores. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro and bromo groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic amine functionality.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, photoaffinity labels, and other molecular probes for studying biological systems.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	5-Bromo-2,3-Difluorobenzyl Amine
CAS No.	887585-92-4
Molecular Formula	C7H6BrF2N
Molecular Weight	222.03 g/mol
Synonyms	(5-Bromo-2,3-difluorophenyl)methanamine; 1-(Aminomethyl)-5-bromo-2,3-difluorobenzene; 5-Bromo-2,3-difluorobenzylamine; 2,3-Difluoro-5-bromobenzylamine; α-Amino-5-bromo-2,3-difluorotoluene; Benzenemethanamine, 5-bromo-2,3-difluoro-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,3-Difluorobenzyl Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.