Description

n-[2-(Bromomethyl)Phenyl]-2,2,2-Trifluoroacetimidoyl Chloride CAS NO 887497-69-0 is a specialized, high-value organobromine and organofluorine building block. This compound is critical for introducing the 2-(bromomethyl)phenyl and trifluoroacetimidoyl chloride functionalities into complex molecular architectures. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting protease inhibitors and other biologically relevant scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for constructing molecules with specific steric and electronic properties.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the bromomethyl and trifluoromethyl groups enhance biological activity and metabolic stability.
• Chemical Biology Probes: Serves as a versatile reagent for labeling and modifying biomolecules in proteomics and bio-conjugation studies.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials that require halogenated aromatic components.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form complex biaryl systems.
• Fluorine Chemistry: An essential building block for introducing the trifluoroacetimidoyl group, a valuable motif in medicinal chemistry for improving lipophilicity and metabolic resistance.

Basic Information

Product Name	n-[2-(Bromomethyl)Phenyl]-2,2,2-Trifluoroacetimidoyl Chloride
CAS No.	887497-69-0
Molecular Formula	C10H8BrClF3NO
Molecular Weight	314.53 g/mol
Synonyms	2-(Bromomethyl)phenyl Trifluoroacetimidoyl Chloride; N-[2-(Bromomethyl)phenyl]-2,2,2-trifluoroethanimidoyl Chloride; 1-[2-(Bromomethyl)phenyl]-2,2,2-trifluoroethanimidoyl Chloride; α-Bromo-o-xylene Trifluoroacetimidoyl Chloride; (2-(Bromomethyl)phenyl)(trifluoroacetyl)imino Chloride; Trifluoro-N-(2-(bromomethyl)phenyl)acetimidoyl Chloride
EINECS	Contact for details

Quality Control

Our n-[2-(Bromomethyl)Phenyl]-2,2,2-Trifluoroacetimidoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.