Description

1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-3-Carboxaldehyde is a high-value, multi-functional chemical building block that combines a pyrazole core with a pinacol boronate ester and an aldehyde group. This unique structure makes it a critical intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex heterocyclic compounds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to construct novel pyrazole-based herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED emitters and charge transport layers.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes and bioconjugates for target identification and validation.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel and combinatorial chemistry approaches.
• Ligand and Catalyst Development: Used to prepare novel bidentate and polydentate ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-3-Carboxaldehyde
CAS No.	887475-64-1
Molecular Formula	C11H17BN2O3
Molecular Weight	236.08 g/mol
Synonyms	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbaldehyde; 3-Formyl-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1-Methyl-4-(pinacolatoboryl)-1H-pyrazole-3-carboxaldehyde; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrazole-3-carbaldehyde; 1-Methyl-4-(pinacol boronate)-1H-pyrazole-3-carboxaldehyde; 1-Methyl-4-boronic acid pinacol ester pyrazole-3-carboxaldehyde; 4-BPin-1-methyl-1H-pyrazole-3-carbaldehyde
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-3-Carboxaldehyde adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed under an inert atmosphere to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.