Description

(2R)-2-(Ethoxycarbonyl)-1,1,1-Trifluoro-4-Methylpent-4-En-2-Ol is a high-purity chiral trifluoromethylated building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both a stereogenic center and a reactive trifluoromethyl group, enabling the efficient construction of complex, fluorinated target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Advanced Material Precursor: Serves as a building block for specialty polymers and liquid crystals that require fluorinated segments for specific thermal or optical properties.
• Asymmetric Catalysis Research: Employed as a standard substrate or ligand precursor in methodological studies to develop new catalytic asymmetric transformations.
• Fluorine Chemistry R&D: A valuable compound for investigating new C-F bond formation reactions and the stereoselective introduction of fluorinated groups into organic frameworks.

Basic Information

Product Name	(2R)-2-(Ethoxycarbonyl)-1,1,1-Trifluoro-4-Methylpent-4-En-2-Ol
CAS No.	887375-49-7
Molecular Formula	C10H13F3O3
Molecular Weight	238.20 g/mol
Synonyms	(R)-Ethyl 2-hydroxy-4-methyl-1,1,1-trifluoro-4-penten-2-oate; (R)-Ethyl 2-hydroxy-4-methyl-1,1,1-trifluoropent-4-en-2-oate; (2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol; (R)-1,1,1-Trifluoro-4-methyl-4-pentene-2-ol-2-carboxylic acid ethyl ester; Ethyl (R)-2-hydroxy-4-methyl-1,1,1-trifluoropent-4-en-2-oate; Chiral Trifluoromethyl Building Block 887375-49-7
EINECS	Contact for details

Quality Control

Our production of (2R)-2-(Ethoxycarbonyl)-1,1,1-Trifluoro-4-Methylpent-4-En-2-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, 1H/19F/13C NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.