Description

2-(1,1,2,2,2-Pentafluoroethyl)-2-[3-(Trifluoromethyl)Phenyl]Pyrrolidine is a high-value, fluorinated pyrrolidine derivative, a key structural motif in modern pharmaceutical and agrochemical discovery. Its unique perfluoroalkyl and trifluoromethylphenyl substituents make it a versatile and valuable advanced pharmaceutical intermediate (API) for synthesizing compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is primarily sought by R&D and process chemistry teams in the pharmaceutical and crop protection industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty fluorinated polymers and liquid crystals with unique surface properties and chemical resistance.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to modulate the physicochemical properties of bioactive molecules.
• Process Development: Used for scaling up synthetic routes in pilot plants and commercial manufacturing of fluorinated active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Item	Detail
Product Name	2-(1,1,2,2,2-Pentafluoroethyl)-2-[3-(Trifluoromethyl)Phenyl]Pyrrolidine
CAS No.	887360-99-8
Molecular Formula	C13H11F8N
Molecular Weight	333.22 g/mol
Synonyms	2-(Pentafluoroethyl)-2-[3-(trifluoromethyl)phenyl]pyrrolidine; 2-(1,1,2,2,2-Pentafluoroethyl)-2-(3-(trifluoromethyl)phenyl)pyrrolidine; 2-(Perfluoroethyl)-2-(3-trifluoromethylphenyl)pyrrolidine; 2-(3-Trifluoromethylphenyl)-2-(pentafluoroethyl)pyrrolidine; Pyrrolidine, 2-(1,1,2,2,2-pentafluoroethyl)-2-[3-(trifluoromethyl)phenyl]-; CAS 887360-99-8
EINECS	Contact for details

Quality Control

Our 2-(1,1,2,2,2-Pentafluoroethyl)-2-[3-(Trifluoromethyl)Phenyl]Pyrrolidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.