Description

2-Bromo-4-Methyl-1-(Trifluoromethoxy)Benzene is a high-purity, multi-functional aromatic building block designed for advanced chemical synthesis. This compound is valued for its unique combination of bromine and trifluoromethoxy substituents, which introduce both halogen reactivity and enhanced lipophilicity into target molecules. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for bioactivity or as a handle for further functionalization via cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve metabolic stability and membrane permeability.
• Material Science Research: Serves as a monomer or precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and heterocyclic structures.
• Chemical Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-Bromo-4-Methyl-1-(Trifluoromethoxy)Benzene
CAS No.	887268-25-9
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	1-Bromo-2-methyl-4-(trifluoromethoxy)benzene; 2-Methyl-4-(trifluoromethoxy)bromobenzene; 2-Bromo-4-methylanisole, trifluoro derivative; 4-Methyl-2-bromo(trifluoromethoxy)benzene; o-Bromo-p-methyl(trifluoromethoxy)benzene; Benzene, 2-bromo-4-methyl-1-(trifluoromethoxy)-; (Trifluoromethoxy)-2-bromo-4-methylbenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Methyl-1-(Trifluoromethoxy)Benzene is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.